Morning & night. Saturate a cotton pad with Micro-Molecule Gentle Cleansing Solution to wipe over the face removing make-up and debris. If heavy make-up is present, a second round of wiping may be required. No rinsing off or water required. Apply Meso-Moist Treatment Essence, followed by Pomegranate Intense Hydration Cream over the entire face evenly and gently pat for penetration.